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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1002/lapl.200910142

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1573-904X

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Micellar Nanocarriers Potential NosetoBrain Del

Authors: Ratnesh Jain Swapna Nabar Prajakta Dandekar Vandana Patravale
Publish Date: 2010/02/12
Volume: 27, Issue: 4, Pages: 655-664
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Abstract

The micellar nanocarrier was successfully formulated and characterized for particle size and shape by multiangle dynamic light scattering small angle neutron scattering and cryotransmission electron microscopy Toxicity and biodistribution studies were carried out in rat The distribution of the nasally administered labeled micellar nanocarrier in various regions of the rat brain was determined using the brain localization and autoradiography studiesMicellar nanocarrier of zolmitriptan with size of around 23 nm was successfully formulated The spherical nature of the nanocarrier was confirmed using DLS SANS and cryoTEM Toxicity studies indicated the safety for administration in the nasal cavity In vivo biodistribution studies indicated the superiority of the developed nanocarrier for brain targeting when compared with the intravenous and nasal solutions of the drug Brain localization and autoradiography studies illustrated the distribution of the drug in various regions of the brain and revealed a possible nosetobrain transport pathway for the labeled drugThe authors are thankful to Archarchem Pharmaceuticals Pvt Ltd and Chokhani Pharmaceutical Ltd for the gift sample of zolmitriptan Gattefosse Mumbai India and BASF India Ltd for the gift sample of excipients and Aptar Pharma India Pvt Ltd Mumbai India for the kind gift of Equadel™ Pump The authors are grateful to Lalit Borde and Dr Krishanu Ray from Tata Institute of Fundamental Research Mumbai India Prof Katarina Edwards Uppsala University Uppsala Sweden and Prof Ishi Talmon Haifa Israel for conducting the cryoTEM analysis The authors are thankful to Dr P A Hassan Dr V K Aswal for DLS and SANS analysis and Dr Tanuja Shet for authoradiography Studies Ratnesh Jain is thankful to the Board of Research in Nuclear Sciences Sanction No 2006/35/11/BRNS Department of Atomic Energy Gov’t of India for providing the funding to execute the research

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