Authors: Jason T McConville Kirk A Overhoff Prapasri Sinswat Jason M Vaughn Bradi L Frei David S Burgess Robert L Talbert Jay I Peters Keith P Johnston Robert O Williams
Publish Date: 2006/05/05
Volume: 23, Issue: 5, Pages: 901-911
Abstract
Three ITZ formulations were prepared and characterized in the dry state using contact angle dissolution Xray powder diffraction scanning electron microscopy and Brunauer–Emmett–Teller surface area analysis Aerodynamic particle size distributions and lung deposition studies in 14 outbred male ICR mice were performed using aqueous dispersions of all the formulations A separate dosing uniformity study was also performed to qualify use of the chamberAll formulations had an aggregated particle size of approximately 30 μm in diameter Two formulations showed that 80 of the drug dissolved in less than 5 min The remaining ITZ formulation had a slower dissolution and the lowest total emitted dose from the nebulizer used High concentrations of ITZ were shown to be present in the mouse lung during the lung deposition study up to 168 ± 013 μg/g ± SE were achieved Concentrations of up to 076 ± 003 μg/g ± SE could be maintained from the single nebulized dose for at least 24 h
Keywords: