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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1007/bf00569108

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1573-904X

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High Sensitivity Differential Scanning Calorimetry

Authors: Mark Saunders Kevin M G Taylor Duncan Q M Craig Karen Palin Hazel Robson
Publish Date: 2007/06/06
Volume: 24, Issue: 10, Pages: 1954-1961
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Abstract

Large unilamellar liposomes of EDMPC with DOPE mol ratio 0–50 were prepared Plasmid DNA was added to give a final DNA/lipid −/+ charge ratio of 05 Samples were placed into an HSDSC and cooled to 3°C held isothermally for 30 min and then the temperature was ramped to 120°C at a rate of 1°C/minOn heating EDMPC liposomes the main phase transition occurred at 212°C with a low temperature shoulder on the endothermic peak At low DOPE concentrations the main phase transition temperatures and enthalpies of transition were lower than for pure EDMPC with a peak corresponding to a pure EDMPC phase occurring at DOPE concentrations of 12–17 mol At 50 mol no main transition endotherm was observed DNA solution produced two endothermic peaks with numerous ‘satellite’ peaks indicating thermal denaturation DNA binding to EDMPC changed the shape of the thermogram indicating alteration in lipid packing within the bilayer DNA induced demixing in the bilayers of DOPEcontaining liposomes

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