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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1007/s10967-008-7384-3

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1573-904X

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Evaluation of Osteoclastogenesis via NFκB Decoy/ma

Authors: Thuy Duong Dinh Yuriko Higuchi Shigeru Kawakami Fumiyoshi Yamashita Mitsuru Hashida
Publish Date: 2011/01/21
Volume: 28, Issue: 4, Pages: 742-751
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Abstract

Primary cultured macrophages and bone marrow cells were prepared from mice As macrophagetargeted carriers Mannosylated cationic liposomes Manliposomes were prepared and were allowed to form complexes with NFκB decoy a doublestranded oligonucleotide Cellular uptake inhibition of NFκB activation and cytokine production were evaluated using macrophages Osteoclastogenesis was investigated using bone marrow cells which were cultured in the conditioned medium prepared from macrophages with or without Manliposome/NFκB decoy complexes treatmentCellular accumulation of NFκB decoy was enhanced by Manliposome NFκB activation in macrophages and TNFα production were suppressed in macrophages by Manliposome/NFκB decoy complexes but not by the naked NFκB decoy Galliposome/NFκB decoy complexes or Manliposome/random decoy complexes Osteoclastogenesis of bone marrow cells was induced in the conditioned medium prepared from activated macrophages but not by activated macrophages treated with Manliposome/NFκB decoy complexesOsteoclastogenesis induced by activated macrophages could be suppressed by the treatment macrophages with Manliposome/NFκB decoy complexes Macrophagetargeted delivery of NFκB decoys using Manliposomes may be promising in its use for the remediation of bone lossThis work was supported in part by GrantinAids for Scientific Research from the Ministry of Education Culture Sports Science and Technology of Japan and by Health and Labour Sciences Research Grants for Research on Advanced Medical Technology from the Ministry of Health Labour and Welfare of Japan

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