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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1016/0734-9750(96)84893-2

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1573-904X

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Targeted Delivery to Neuroblastoma of Novel siRNA

Authors: Joanna E Adrian Alexander Wolf Annette Steinbach Jochen Rössler Regine Süss
Publish Date: 2011/05/19
Volume: 28, Issue: 9, Pages: 2261-
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Abstract

Liposomes containing siRNA were prepared by combining the novel dual asymmetric centrifugation DAC method and the recently optimised sterolbased postinsertion technique SPIT to couple antiGD2 antibody for selective interaction with neuroblastoma cells Cultured human neuroblastoma cell lines were used to evaluate the efficiency of siRNA deliveryThe size of liposomes prepared by DAC ranged from 190 to 240 nm siRNA encapsulation efficiency was up to 50 An average of 70 and 100 molecules of antiGD2 antibody per particle were coupled A significant association of liposomes with neuroblastoma cells as well as effective siRNA delivery was observed only when antiGD2 antibody was coupled Preliminary data suggest delivery of siRNA using antiGD2liposomes occurs via GD2mediated endocytosis Vascular endothelial growth factor A VEGFA was downregulated using siRNA delivered by antiGD2liposomes

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