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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1016/0160-2527(84)90003-7

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1573-904X

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Targeted Delivery of Complexes of Biotin–PEG–Polye

Authors: Raktima Bhattacharya Berit Osburg Dagmar Fischer Ulrich Bickel
Publish Date: 2007/10/20
Volume: 25, Issue: 3, Pages: 605-615
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Abstract

Complexes of ODNs and a copolymer of biotin–polyethylenglycol and polyethylenimine BPP were targeted to brainderived endothelial cells with a conjugate of antibody 8D3 and streptavidin 8D3SA Size and stability of ODN/BPP complexes was measured by dynamic light scattering Cellular uptake was studied by confocal microscopy Cell viability and pharmacological effects were investigated on murine bEnd5 cells stimulated with tumor necrosis factorODN/BPP complexes showed sizes of 116 ± 23 nm which increased by 40 nm when coupled to 8D3SA and were stable in physiological fluids Targeted complexes were internalized intact into endosomal compartments Treatment conditions which yielded significant inhibitory effects on mRNA expression of VCAM1 ICAM1 IκBα and iNOS by bEnd5 cells did not affect viability At 05 μM decoy ODN significantly inhibited monocyte adhesion to bEnd5 monolayers when delivered as 8D3SAtargeted complex while higher concentrations of untargeted complex were ineffective

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