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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1016/0021-9290(85)90672-4

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1573-904X

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Tumor Environment Changed by Combretastatin Deriva

Authors: Kouichi Shiraishi Yoshiko Harada Kumi Kawano Yoshie Maitani Katsuyoshi Hori Kazuyoshi Yanagihara Misato Takigahira Masayuki Yokoyama
Publish Date: 2011/07/26
Volume: 29, Issue: 1, Pages: 178-186
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Abstract

Significantly higher accumulation of the MRI contrast agent was found in tumor tissues when Cderiv was administered at 72 h before MRI contrast agent injection T1weighted images of the tumor exhibited substantial signal enhancement in tumor area at 24 h after the contrast agent injection In T1weighted images remarkable T1signal enhancements were observed in part of tumor not in whole tumor These results indicate that Cderiv pretreatment considerably enhanced the permeability of the tumor blood vessels Antitumor activity of adriamycin encapsulated polymeric micelles with the Cderiv pretreatment suppressed tumor growth in 44As3 human gastric scirrhous carcinomabearing nude mice

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