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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1006/jsvi.2000.2951

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ISSN

1573-904X

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Screening of Chemical Penetration Enhancers for Tr

Authors: Vijay Krishna Rachakonda Krishna Mohan Yerramsetty Sundararajan V Madihally Robert L Robinson Khaled A M Gasem
Publish Date: 2008/08/06
Volume: 25, Issue: 11, Pages: 2697-
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Abstract

Specifically a multiwell resistance chamber was designed and constructed to facilitate more rapid determination of the effect of CPEs on skin resistance The experimental setup was validated using nicotine and decanol on porcine skin in vitro The multiwell resistance chambers were capable of operating at 37°C in order to simulate the physiological temperature of the human body Further the utility of the multiwell resistance chamber technique was validated using standard Franz diffusion cells Electrical resistance measurements were used to evaluate the potency of seven new potential CPEs identified using virtual screening algorithms From the resistance measurements the chemicals 1dodecyl2pyrrolidinone P menthone M and R+3amino1hydroxy2pyrrolidinone C were identified as the better penetration enhancers among the seven tested Further traditional permeation experiments were performed in Franz diffusion cells to confirm our findings

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