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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1007/1-4020-8131-6_2

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1573-904X

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Triggered Emphasis Type="Italic"In Situ/Emphasi

Authors: F Benaouda M B Brown G P Martin S A Jones
Publish Date: 2012/08/30
Volume: 29, Issue: 12, Pages: 3434-3442
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Abstract

A propylene glycol PG/water hydroxypropyl methyl cellulose matrix containing ethanol was used to support diclofenac supersaturation Phase behaviour thermodynamics and drug transport were assessed through the determination of evaporation kinetics supersaturation kinetics and transmembrane penetrationInitial ethanol evaporation from the drug loaded matrix 29 ± 04 mgmin−1cm−2 was comparable to that of the pure solvent ca 3 mgmin−1cm−2 When 25 w/w of the total ethanol from the applied phase was lost ethanol/water/PG molar ratio of 7512 an inflection point in the evaporation profile and a sudden decrease in drug solubility demonstrated that a defined supramolecular structure was formed The 55fold decrease in drug solubility observed over the subsequent 8 h drove in situ supersaturation the rate of which was a function of the drug load in the matrix y = 00078x R2  099

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