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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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10.1007/s00784-010-0482-y

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1573-904X

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Hydroxylation of Emphasis Type="Italic"R/Emphas

Authors: Hideo Shiohira Norio YasuiFurukori Satoshi Yamada Tomonori Tateishi Yumiko Akamine Tsukasa Uno
Publish Date: 2012/05/02
Volume: 29, Issue: 8, Pages: 2310-2316
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Abstract

After single IV administration of racemic omeprazole 20 mg the mean area under the plasma concentrationtime curve AUC0∞ of R+omeprazole in PMs was significantly higher than that in hmEMs and htEMs while that of S−omeprazole was no significance among three genotypes because of a wide interindividual variability In addition although the AUC0∞ of R+5hydroxyomeprazole were determined among three genotypes the that of S−5hydroxyomeprazole was undetectable in the hmEMs and barely detectable in the htEMs Conversly the AUC0∞ of S−5hydroxyomeprazole was greater than that of R+5hydroxyomeprazole in the PMsThese data therefore suggest that for EMs the CYP2C19mediated formation from R+enantiomer is a 5hydroxymetabolite while that from S−enantiomer may be a minor metabolite Thus the in vivo disposition of S− and R+omeprazole after racemic dosing may be different among the CYP2C19 genotypes

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