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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1016/0012-1606(92)90199-q

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1573-904X

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The Effect of Polymeric Excipients on the Physical

Authors: Jinjiang Li Junshu Zhao Li Tao Jennifer Wang Vrushali Waknis Duohai Pan Mario Hubert Krishnaswamy Raghavan Jatin Patel
Publish Date: 2014/08/09
Volume: 32, Issue: 2, Pages: 500-515
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Abstract

Two drugs indomethacin and ketoconazole were selected to prepare amorphous dispersions with PVP PVPVA HPC and HPMCAS through spray drying The physical attributes of the dispersions were characterized using SEM and PXRD The free volume holesize of the dispersions along with drugs and polymers was measured using positron annihilation lifetime spectroscopy PALS Their glass transition temperatures Tgs were determined using DSC and DMA FTIR spectra were recorded to identify hydrogen bonding in the dispersionsThe chain structural differenceflexible PVP and PVPVA vs inflexible HPC and HPMCASsignificantly impacts the free volume and Tgs of the dispersions as well as their deviation from ideality Relative to Tg free volume seems to be a better measure of hydrogen bonding interaction for the dispersions of PVP HPC and HPMCAS The free volume of polymers and their dispersions in general appears to be related to their conformations in solutionAuthors would like to thank the management of Drug Product Science Technology at BristolMyers Squibb for financial support as well as Prof Nazarenko and Mr Goetz of the University of Southern Mississippi for providing free volume and fractional free volume results used in this paper and supplying the experimental procedure used In addition authors are grateful to Dr Hussain of BristolMyers Squibb for reading the manuscript

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