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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Publisher

Springer US

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DOI

10.1007/s002290170019

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ISSN

1573-904X

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Cationic Liposomal Codelivery of Small Interferin

Authors: Seung Hee Kang HeeJeong Cho Gayong Shim Sangbin Lee SuHyeon Kim HanGon Choi ChanWha Kim YuKyoung Oh
Publish Date: 2011/08/31
Volume: 28, Issue: 12, Pages: 3069-3078
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Abstract

MEK inhibitor PD0325901 was encapsulated in lipid layers of NNdioleylglutamidebased cationic liposomes DGL Mcl1specific siRNA siMcl1 was complexed to DGL or PD0325901loaded liposomes PDGL Efficiency of cellular siRNA delivery was tested using fluorescent doublestranded RNA Silencing of target proteins was evaluated using Western blotting and realtime quantitative polymerase chain reactions In vivo anticancer activity was tested using xenografted miceSize and zeta potential of PDGL were similar to DGL PDGL could deliver doublestranded RNA into cells with efficiencies comparable to DGL Cellular codelivery of siMcl1 and PD0325901 reduced expression of Mcl1 and pERK1/2 proteins and more effectively reduced tumor cell survival than other treatments In mice siMcl1 and PD0325901 codelivered by PDGL inhibited growth of tumors 79 Substantial apoptosis of tumor cells was observed following PDGLmediated codelivery of siMcl1 but not in other groups

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