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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1007/s00115-005-1965-y

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1573-904X

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HCV J6/JFH1 Tilts the Capability of MyeloidDerive

Authors: Zhong Fang Kai Zhu Nining Guo Na Zhang Mo Guan Chunfu Yang Qinsong Pan Ruicheng Wei Chunhui Yang Chaoyang Deng Xiaoqing Liu Ping Zhao Qibin Leng
Publish Date: 2013/04/26
Volume: 32, Issue: 3, Pages: 741-748
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Abstract

How HCV virus affects the function of dendritic cells DCs and their ability to induce CD4+ T cell response remains not fully understood This study was done to elucidate the impact of HCV on the function of DCs and on DC’s capability to induce CD4+ Tcell responseMonocytederived DCs MoDCs were treated with cellculture HCV HCVcc The effects of HCVcc on DC maturation CD40Linduced DC maturation and cytokine production and the capacity of DCs to induce Th cytokine production of allogeneic CD4+ T cells were evaluatedHCVcc exposure increased expression of both IL6 and IL10 by MoDCs HCVexposed MoDCs also selectively facilitated allogeneic CD4+ T cells to further produce Th17related cytokines interleukin 1 IL1 IL6 and IL17A Pretreatment of IL17A inhibited HCV production in Huh75 cells suggesting that induction of Th17 cells may be beneficial to host antiHCV immunity Paradoxically induction of IL10 expression and the failure of HCVexposed MoDCs to facilitate other Th cell development may hinder the antiviral immunityWe are grateful to Dr Charles M Rice for providing J6/JFH1 chimeric genome plasmid and Huh75 cells We thank Drs Jin Zhong Qiang Deng and Jianhua Wang for technical advice This work was supported by the National Basic Research Program of China 973 Program no 2009CB522507 and the National Natural Science Foundation of China program no 30972726 QL is supported by the SASIBS Scholarship Program

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