Authors: Huseyin Oflaz Ramazan Kurt Fatma Sen Imran Onur Arif Oguzhan Cimen Ali Elitok Kultigin Turkmen Burak Pamukcu Erdem Kasikcioglu Zehra Bugra Fehmi Mercanoglu Nese Ozbey
Publish Date: 2008/01/26
Volume: 32, Issue: 3, Pages: 264-270
Abstract
Backgound/Aims Overt and subclinical hypothyroidism are reported to be associated with increased cardiovascular disease risk We have used coronary flow reserve CFR measurement by transthoracic Doppler echocardiography TTDE to determine coronary microvascular function in Hashimoto’s thyroiditis patients with overt and subclinical hypothyroidism and to evaluate effects of lthyroxine replacement on coronary endothelial function Methods In total 10 overt hypothyroid patients 10 subclinical hypothyroid patients and 10 controls were enrolled FT4 TSH antithyroid antibodies lipid profile insulin glucose HOMAIR physical parameters and CFR measured by TTDE were recorded before and after 6 months of lthyroxine replacement in all groups Results CFR values of all hypothyroid patients at baseline were significantly lower than those in controls After lthyroxine CFR increased significantly in overt and subclinical hypothyroidism with respect to the baseline measurements P 005 When baseline and second measurements were evaluated collectively for patients and controls CFR was positively correlated with FT4 levels r = 031 P = 001 and negatively correlated with TSH and HOMAIR r = −038 P = 0002 and r = −042 P 0001 respectively Conclusion Subclinical as well as overt hypothyroid patients have impaired coronary microvascular function which improved after lthyroxine therapy Treatment of Hashimoto’s thyroiditis patients with subclinical hypothyroidism should be considered to improve cardiovascular disease risk
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