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Title of Journal: Endocrine

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Abbravation: Endocrine

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Springer US

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DOI

10.1007/s40278-015-8288-y

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1559-0100

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Long noncoding RNA ENSMUST00000147869 protects me

Authors: Min Wang Di Yao Suyu Wang Qin Yan Weiping Lu
Publish Date: 2016/04/15
Volume: 54, Issue: 1, Pages: 81-92
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Abstract

Diabetic nephropathy as the primary cause of endstage renal disease reveals an increased incidence in patients with kidney disease as the continuous rising of type 2 diabetes Long noncoding RNAs lncRNAs are involved in the development of many diseases including diabetes however the role of lncRNAs in diabetic nephropathy is still unclear In the present study lncRNA microarray analysis was used to identify abnormally expressed lncRNAs and nearby mRNAs in renal cortical tissues dissected from kidney of db/db and db/m mice After verifying the data from microarray analysis by quantitative RTPCR downregulated ENSMUST00000147869 associated with Cyp4a12a was selected for overexpression in mouse mesangial cells among differentially expressed lncRNAs Cell Counting Kit8 Western blotting and quantitative RTPCR showed that proliferation and fibrosis indexes were reversed in mesangial cells with ENSMUST00000147869 overexpression Our data suggested the potential role of ENSMUST00000147869 in proliferation and fibrosis of mesangial cells which provided a molecular biomarker and therapeutic target for diabetic nephropathy

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