Journal Title
Title of Journal: Endocrine
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Authors: Yuki Nagata Yasuo Imanishi Akira Ishii Masafumi Kurajoh Koka Motoyama Tomoaki Morioka Hiroshi Naka Katsuhito Mori Takami Miki Masanori Emoto Masaaki Inaba
Publish Date: 2011/08/06
Volume: 40, Issue: 2, Pages: 315-
Abstract
Nterminal propeptide of type I procollagen PINP is a marker of newly formed type I collagen However its role in hypophosphatemic rickets/osteomalacia has not yet been established Metabolic bone markers were examined in patients with oncogenic osteomalacia OOM and Xlinked hypophosphatemic rickets XLH and in healthy controls OOM and XLH patients were found to have hypophosphatemia secondary to elevated levels of serum fibroblast growth factor 23 FGF23 OOM patients had reduced levels of 125dihydroxy vitamin D 125D compared with XLH patients and healthy controls despite attenuation of the reduction in these levels in the XLH patients secondary to active vitamin D supplementation In contrast to patients with XLH OOM patients showed a significant increase in serum PINP which is suggestive of accelerated bone matrix formation Bone alkaline phosphatase BAP and the BAP/PINP ratio were also increased in OOM but not in XLH patients suggesting the presence of a disturbance in bone mineralization in OOM Longterm supplementation of active form vitamin D and inorganic phosphate IP may have attenuated the defect in bone mineralization in the XLH patients resulting in the normalization of PINP BAP and the BAP/PINP ratio The present results suggest that as with BAP PINP is an appropriate metabolic bone marker in the assessment of hypophosphatemic rickets/osteomalaciaThe authors are grateful to Fujirebio Inc for their technical assistance in the measurement of serum PINP This study was supported by two GrantsinAid for the Scientific Research C 20591101 and 20590980 and a grant from The Kidney Foundation Japan JKFB119All participants provided written informed consent before inclusion This study was approved by the ethics committee of the Osaka City University Graduate School of Medicine and was conducted in accordance with the principles of the Declaration of Helsinki
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