Longitudinal associations between lifestyle and vi

Authors: Tea Skaaby Lise Lotte Nystrup Husemoen Betina Heinsbæk Thuesen Charlotta Pisinger Anke Hannemann Torben Jørgensen Allan Linneberg

Publish Date: 2015/05/30

Volume: 51, Issue: 2, Pages: 342-350

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Abstract

Several lifestyle factors have been found to be associated with vitamin D status in crosssectional studies but it is not clear whether a change in these factors can actually affect the vitamin D level We investigated the association between repeated measurements of physical activity body mass index BMI diet alcohol consumption and smoking habits and corresponding levels of vitamin D during 5 years of followup of a large general population sample We included 4185 persons who participated and had vitamin D serum25hydroxyvitamin D 25OHD measurements in the Inter99 study at baseline 1999–2001 and 5year followup In a subsample 25OHD was also measured at 1 and 3year followups We used mixed models to examine the association between repeated measurements of lifestyle factors and 25OHD levels In multivariable analyses of repeated measurements the difference in 25OHD was −032 ng/ml 95  CI −037 −028 per 1 kg/m2 increase in BMI 450 ng/ml 95  CI 384 515 for persons moderately/vigorously physically active versus sedentary 182 ng/ml 95  CI 109 256 for persons with healthy versus unhealthy dietary habits 005 ng/ml 95  CI 003 007 per 1 standard drink/weak increase in alcohol consumption and 086 ng/ml 95  CI 036 135 for never smokers versus daily smokers Our study shows that lower BMI a higher level of physical activity a healthier diet and possibly a higher alcohol intake and not smoking are associated with higher 25OHD levelsThe present study was financially supported by the Health Insurance Foundation Grant No 2010 B 131 We would like to thank the participants and all members of the Inter99 staff at Research Centre for Prevention and Health The Inter99 study was initiated by Torben Jørgensen DMSci principal investigator Knut BorchJohnsen DMSci coprincipal investigator Troels Thomsen PhD and Hans Ibsen DMSci The Steering Committee comprises Torben Jørgensen and Charlotta Pisinger PhD MPH

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