Authors: Kerem Ersoy İnan Anaforoğlu Ekrem Algün
Publish Date: 2012/09/23
Volume: 43, Issue: 2, Pages: 430-433
Abstract
Overt hypothyroidism and subclinical hypothyroidism are thought to be associated with atherosclerosis and a chronic ischemic process Ischemic modified albumin IMA is a novel marker of ischemia We examined serum IMA levels in patients with subclinical and overt hypothyroidism We recruited patients who presented to our clinic for thyroid disease control We compared demographic data fasting blood sugar serum lipid levels and the prevalence of metabolic syndrome by the presence of overt subclinical and no hypothyroidism Cobalt binding to albumin capacity was analyzed using a rapid colorimetric technique and compared among the groups We assessed 11 men and 74 women with a mean age of 399 ± 12 years Of these 48 565 were euthyroid 24 282 had subclinical hypothyroidism and 13 153 had overt hypothyroidism The groups did not differ significantly in terms of age body mass index waist circumference systolic and diastolic blood pressures levels of fasting and nonfasting blood sugar high and lowdensity lipoproteins and triglycerides and the presence of metabolic syndrome Mean serum IMA level also did not differ significantly among the groups 020 ± 008 absorbance units ABSU in the euthyroid participants 018 ± 008 ABSU in those with subclinical hypothyroidism and 020 ± 009 ABSU in those with overt hypothyroidism P = 0754 Mean IMA values did not differ significantly by sex cigarette use the presence of metabolic syndrome or the presence of thyroid autoantibodies Serum IMA levels did not differ among patients with overt or subclinical hypothyroidism in this casecontrol study
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