Authors: Askin Gungunes Mustafa Sahin Taner Demirci Bekir Ucan Evrim Cakir Muyesser Sayki Arslan Ilknur Ozturk Unsal Basak Karbek Mustafa Calıskan Mustafa Ozbek Erman Cakal Tuncay Delibasi
Publish Date: 2014/04/17
Volume: 47, Issue: 3, Pages: 895-900
Abstract
Cushing’s syndrome may be more frequent in some specific patient groups such as type 2 diabetes and obesity The aim of this study was to investigate the prevalence of Cushing’s syndrome in outpatients with type 2 diabetes with poor glycemic control despite at least 3months insulin therapy Outpatients with type 2 diabetes whose glycemic control is poor Hb Alc value 7 despite receiving at least 3months long insulin treatment insulin alone or insulin with oral antidiabetics were included Patients with classic features of Cushing’s syndrome were excluded Overnight 1 mg dexamethasone suppression test DST was performed as a screening test A total of 277 patients with type 2 diabetes whose glycemic control is poor Hb Alc value 7 despite insulin therapy were included Two of the 277 patients with type 2 diabetes were diagnosed with Cushing’s syndrome 072 Hypertension was statistically more frequent in the patients with cortisol levels ≥18 μg/dL than the patients with cortisol levels 18 μg/dL after overnight 1 mg DST p = 0041 Statistically significant correlation was determined between cortisol levels after 1 mg DST and age daily insulin dose r = 0266 and p 0001 r = 0163 and p = 0008 respectively According to our findings the prevalence of Cushing’s syndrome among patients with type 2 diabetes with poor glycemic control despite insulin therapy is much higher than in the general population The patients with type 2 diabetes with poor glycemic control despite at least three months of insulin therapy should be additionally tested for Cushing’s syndrome if they have high dose insülin requirements
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