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Title of Journal: Endocrine

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Abbravation: Endocrine

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Springer US

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1559-0100

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Lifetime untreated isolated GH deficiency due to

Authors: Anita H O Souza Maria I T Farias Roberto Salvatori Gabriella M F Silva João A M Santana Francisco A Pereira Francisco J A de Paula Eugenia H O Valença Enaldo V Melo Rita A A Barbosa Rossana M C Pereira Miburge B GoisJunior Manuel H AguiarOliveira
Publish Date: 2013/11/23
Volume: 47, Issue: 1, Pages: 191-197
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Abstract

The GH/IGFI axis has essential roles in regulating bone and vascular status The agerelated decrease in GH secretion “somatopause” may contribute to osteoporosis and atherosclerosis commonly observed in the elderly Adultonset GH deficiency GHD has been reported to be associated with reduced bone mineral density BMD increased risk of fractures and premature atherosclerosis We have shown the young adult individuals with isolated GHD IGHD due to a homozygous for the c57+1GA GHRH receptor gene mutation have normal volumetric BMD vBMD and not develop premature atherosclerosis despite adverse risk factor profile However the bone and vascular impact of lifetime GHD on the aging process remains unknown We studied a group of ten older IGHD subjects ≥60 years homozygous for the mutation comparing them with 20 age and gendermatched controls CO Areal BMD was measured and vBMD was calculated at the lumbar spine and total hip Vertebral fractures and abdominal aortic calcifications expressed as calcium score were also assessed Areal BMD was lower in IGHD but vBMD was similar in the two groups The percent of fractured individuals was similar but the mean number of fractures per individual was lower in IGHD than CO Calcium score was similar in the two groups A positive correlation was found between calcium score and number of fractures Untreated lifetime IGHD has beneficial consequences on bone status and does not have a deleterious effect on abdominal aorta calcification

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