Journal Title
Title of Journal: Endocrine
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Authors: Alberto Righi Marco FaustiniFustini Luca Morandi Valentina Monti Sofia Asioli Diego Mazzatenta Antonella Bacci Maria Pia Foschini
Publish Date: 2016/08/04
Volume: 56, Issue: 2, Pages: 286-297
Abstract
The spectrum of corticotroph cell adenomas is very wide Though rarely silent corticotroph cell adenomas SCA may transform into corticotroph cell adenomas associated with Cushing’s disease CD The aim of the study was to investigate the role of prohormone convertase 1/3 PC1/3 in the transformation of SCA into CD We reviewed the records of 1259 consecutive endoscopic endonasal procedures for pituitary adenomas from 1998 to 2013 Of these 132 were CD and 44 were SCA During the followup three patients with SCA showed a clear transformation from SCA into CD and underwent surgery once again to remove the recurrent tumour The PC1/3 expression was analysed by both immunohistochemistry and quantitative real timepolymerase chain reaction qRTPCR in primary and recurrent tumours The immunohistochemical PC1/3 expression was negative or weak in the three patients in the initial phase of SCA while a strong expression was observed in the majority of neoplastic cells in tissue specimens obtained from the same three patients at the time of recurrence as CD The immunohistochemical PC1/3 expression showed a strict correlation with the PC1/3 levels obtained by qRTPCR In 14 cases of SCA with no change of phenotype during the followup the immunohistochemical PC1/3 expression was low and strictly associated with the level of PC1/3 obtained by qRTPCR both in primary 14/14 cases and in recurrent tumours 4/4 cases Our study provides insight into the crucial role of the PC1/3 protein in the transformation of phenotype from SCA to CDThe authors thank the following members of the team for their contributions to patient care and data collection Dr Giorgio Frank for his skilful contribution as project manager of the Centre of Pituitary and Endoscopic Skullbase Surgery IRCCS Institute of Neurological Sciences of Bologna ISNB Dr Carmelo Sturiale chief of the Neurosurgery Unit IRCCS Institute of Neurological Sciences of Bologna ISNB
Keywords:
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