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Title of Journal: Endocrine

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Abbravation: Endocrine

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Springer US

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DOI

10.1002/zfch.19790191201

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1559-0100

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Clinical characteristics as predictors of malignan

Authors: Pierpaolo Trimboli Giorgio Treglia Leo Guidobaldi Enrico Saggiorato Giuseppe Nigri Anna Crescenzi Francesco Romanelli Fabio Orlandi Stefano Valabrega Ramin Sadeghi Luca Giovanella
Publish Date: 2013/10/03
Volume: 46, Issue: 1, Pages: 52-59
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Abstract

Indeterminate thyroid nodules ITN constitute the gray zone of thyroid fineneedle aspiration cytology FNAC About 70–80  of ITN are later diagnosed as benign therefore it is very important to identify the predictors of malignancy Aim of the study was to summarize published data about clinical risk factors for malignancy in patients with ITN and thereby provide more robust estimates of the effect of these risk factors Sources comprised studies published through December 2012 Original articles that investigated clinical parameters as potential predictors of malignancy in ITN were identified Two authors performed the data extraction independently A metaanalysis of 19 relevant studies was conducted that included 3494 patients with ITN according to FNAC The pooled prevalence of malignancy was 28  95  CI 23–33 26  in females and 34  in males The pooled OR was 151 95  CI 12–183 for males and 068 95  CI 053–088 for females Regarding the nodule’s size the pooled OR was 210 95  CI 126–350 for nodules 4 cm in diameter Analysis of the patient age as a risk factor was not feasible because of marked difference found between the studies In patients with indeterminate thyroid nodules diagnosed at FNAC the pooled rate of malignancy from 19 studies was 28  Patients that are male and have ITN greater than 4 cm in diameter should be considered at higher risk of cancer

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