Authors: Marta Ragonese Angela Alibrandi Gianluca Di Bella Ignazio Salamone Soraya Puglisi Oana Ruxandra Cotta Maria Luisa Torre Francesco Ferrau Rosaria Maddalena Ruggeri Francesco Trimarchi Salvatore Cannavo
Publish Date: 2013/11/27
Volume: 47, Issue: 1, Pages: 206-212
Abstract
Prediction of ischemic cardiovascular events ICE in acromegalic patients stratified accordingly with Framingham FS and Agatston score AS 32 patients with active group A 0 and 20 with controlled group B 0 acromegaly have been enrolled During the 5year followup 19 out of 32 patients in group A 0 reached disease control At entry FS and AS by an eightslice MDCT scanner were calculated in all patients ICE were diagnosed by autopsy if lethal and by electrocardiography and/or echocardiography if nonlethal Overall 96 of patients died for lethal ICE AS 400 but not high FS at entry was associated with increased risk of lethal ICE Lethal ICE had occurred in two patients of group A 0 and three of group B 0 p NS while a nonlethal ICE had occurred in two cases of the former and in other two of the latter group p NS Either FS or AS was correlated with the risk for ICE overall p 002 but only AS correlated with that of lethal ICE p 00003 Survival analysis demonstrated reduced life expectancy in patients with high FS p 002 In acromegalics AS 400 is associated with increased risk of lethal ICE while high FS is associated with reduced life expectancy regardless of disease control
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