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Title of Journal: Endocr

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Abbravation: Endocrine

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Springer US

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1559-0100

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Regulatory T cells in type 1 diabetic patients wit

Authors: Núria Alonso María Jesús MartínezArconada María Luisa Granada Berta Soldevila Ana Cantón José Luis Mate Anna Sanmartí Eva María MartínezCáceres
Publish Date: 2009/03/17
Volume: 35, Issue: 3, Pages: 420-428
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Abstract

Type A chronic atrophic gastritis CAG is increased in type 1 diabetic patients DM1 To address this issue we determined and analyzed the number of peripheral blood regulatory T cells Tregs in 15 DM1CAG patients 15 DM1 patients without associated autoantibodies DM1 and 15 healthy controls by flow cytometry and compared gastric Tregs expression CD4+Foxp3+/CD4+ in DM1CAG patients with that observed in 10 control Helicobacter pylori CAGinfected biopsies The percentage of peripheral Tregs was higher in DM1CAG patients compared to DM1 and controls CD4+Foxp3+ 767 ± 191 vs 538 ± 157 and 565 ± 176 P  0001 respectively with no differences between DM1 and controls Gastric mucosal Tregs were higher in H pylori CAG than in DM1CAG patients 3131 ± 552 vs 768 ± 370 P  0001 Data suggest that Tregs are stimulated in patients with more than one autoimmune disease DM1 + CAG in an ineffectual attempt to control autoimmune response and that the number of Tregs in gastric mucosa implicated in the chronification of gastritis differs according to the etiologyProf Ricardo Pujol for helpful suggestions and critical reading of the manuscript Prof Mercè Martí for providing us with part of the monoclonal antibodies used in flow cytometric analysis Diogo Baia for technical support in the initial phases of the study and Christine 0’Hara for valuable help with the English version of the manuscript This study was supported in part by the Instituto de Investigación Carlos III grants FIS PI05/0150 to Dr A Sanmartí

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