Authors: Xiaojiao Jia Shuyi Wang Ning Ma Xiaojing Li Likui Guo Xiaoli Liu Tao Dong Yali Liu Qiang Lu
Publish Date: 2014/06/15
Volume: 48, Issue: 2, Pages: 533-540
Abstract
To explore serum vaspin leptin and adiponectin levels and their correlation with insulin resistance IR in pregnant women with and without gestational diabetes mellitus GDM and healthy nonpregnant women A total of 262 individuals including pregnant women with GDM n = 86 those without GDM n = 92 and agematched healthy nonpregnant women n = 84 were enrolled in this case–control study Vaspin leptin adiponectin glucose insulin hemoglobin A1C HbA1c and lipid parameters were measured The homeostasis model assessment–insulin resistance HOMA–IR quantitative insulin sensitivity check index and body mass index were calculated Data inferred higher concentrations of vaspin 272 ± 220 vs 184 ± 157 vs 081 ± 102 in GDM than during normal pregnancy and in nonpregnant women higher leptin 2342 ± 1218 vs 2219 ± 1055 vs 1210 ± 1126 and lower adiponectin 416483 ± 265039 vs 487166 ± 280351 vs 720285 ± 489313 in GDM and normal pregnancy as compared to nonpregnant women p 005 Vaspin was positively correlated to leptin r = 0273 p = 0012 HOMA–IR r = 0387 p = 0000 and triglycerides TG r = 0218 p = 0046 in GDM In addition leptin was negatively correlated to adiponectin in GDM r = −0336 p = 0002 and normal pregnancy r = −0256 p = 0014 Furthermore vaspin was significantly correlated to GDM and HOMA–IR and the weight gain might play a vital role in the occurrence of GDM During pregnancy high vaspin concentration is significantly associated with IR in GDM
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