Authors: Yu Xu Zhiyun Zhao Xiaoying Li Yufang Bi Min Xu Guang Ning
Publish Date: 2010/11/15
Volume: 39, Issue: 2, Pages: 175-181
Abstract
This study is to clarify whether Creactive protein CRP and white blood cell WBC count influence insulin homeostasis to the same degree Serum CRP and peripheral WBC were measured in 739 subjects with normal glucose regulation 512 with impaired glucose regulation and 502 newly diagnosed diabetic patients Levels of insulin resistance IR were assessed using the index of homeostasis model HOMAIR Serum CRP and WBC were significantly correlated with HOMAIR and risk factors of IR Relative risks of IR for each 1SD increase of Ln CRP and Ln WBC were 128 110–147 and 115 101–131 respectively after adjustment for age sex obesity measurements and other traditional risk factors Additional adjustment for WBC slightly attenuated the association between CRP and IR 125 108–145 P = 0003 whereas adjustment for CRP substantially attenuated the association of WBC with IR toward null P = 0134 Moreover individuals with both high levels of CRP and WBC were at higher risks of IR than those with high CRP or WBC alone Both CRP and WBC were significantly associated with risks of IR CRP might be a more effective biomarker in terms of the association with IRWe express our gratitude to all the participants in this study This research was supported by the grants from Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Chinese Public Health No 1994DP131044 National Key New Drug Creation and Manufacturing Program 2008ZX09312/019 Nature Science Foundation No 30800536 Shanghai Commission for Science and Technology No 08ZR1417000
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