Authors: Hye Jin Baek Dong Wook Kim Ji Hwa Ryu
Publish Date: 2014/07/23
Volume: 48, Issue: 2, Pages: 589-594
Abstract
We aimed to assess the validity of the American Joint Committee on Cancer AJCC tumornodemetastasis TNM staging system in patients with papillary thyroid carcinoma PTC by evaluating the relationships between clinicopathologic factors and TNM stage using histopathological specimens and electronic medical records We enrolled 733 consecutive patients who had undergone thyroid surgery for PTC between 2010 and 2013 Clinical data were obtained from electronic medical records TNM stages multifocality and bilaterality were analyzed after review of histopathological specimens by applying the AJCC TNM staging system Multiple statistical analyses were performed to evaluate the correlation between the AJCC TNM staging system and the clinicopathologic factors Of the 733 patients there were T stage including T1a 469 344/733 T1b 126 92/733 T2 20 15/733 T3 381 279/733 T4a 04 3/733 and T4b 0 0/733 N stage including N0 589 432/733 N1a 243 178/733 and N1b 168 123/733 and multiplicity including multifocality 311 228/733 and bilaterality 237 174/733 There was a significant association between the PTC primary tumor size and T stage N stage multifocality and bilaterality p 00001 Multifocality bilaterality and the presence of nodal metastasis were most frequently seen in patients with T3 stage p 00001 In multivariate logistic regression analyses T and N stages were independent predictors of multiple PTCs The PTC primary tumor size had a significant association with the T and N stages of the AJCC TNM staging system and these factors were independent predictors of multifocality and bilaterality
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