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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1007/978-94-017-1400-6_7

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1559-131X

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Serum cytokine levels in patients with advanced no

Authors: Chunxia Su Caicun Zhou Songwen Zhou Jianfang Xu
Publish Date: 2010/08/17
Volume: 28, Issue: 4, Pages: 1453-1457
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Abstract

To investigate whether expression of several cytokines affected clinical outcome in nonsmall cell lung cancer patients A total of 86 stage IIIB/IV nonsmall cell lung cancer patients treated with platinumbased doublets were examined expression levels of IL1 IL2R IL5 IL6 IFNγ TNFα pre and postchemotherapy Enzymelinked immunosorbent assay technique was performed Kaplan–Meier analysis and Cox regression analyses were used to adjust for possible confounding variables IL6 expression levels were significantly decreased due to chemotherapy in patients with stable disease P = 0041 IL2R expression levels were significantly increased due to chemotherapy in patients with progression disease P = 0010 Patients with high concentrations of TNF postchemotherapy had a significantly longer survival P = 0009 17 months versus 11 months than low levels Multivariate analysis showed that sex response rate IL1 and TNFα were significantly predictive of the survival Serum IL6 and IL2R levels correlated with chemoresponse in advanced nonsmall cell lung cancer serum IL1 and TNFα can be predictive factors in advanced nonsmall cell lung cancer

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