Authors: Xuefeng Zhang Gang Li Linkun Hu Xuedong Wei Yueqin Zha Huming Yin Mubin Sun Jun He Jianquan Hou
Publish Date: 2014/11/08
Volume: 31, Issue: 12, Pages: 297-
Abstract
To evaluate the value of resistive index RI of prostatic capsular arteries in diagnosis and evaluation of prostate cancer PCa in Chinese patients undergoing initial prostate biopsy A total of 532 consecutive patients undergoing prostate biopsy were enrolled in this study RI was measured on the largest transverse section of prostate for each individual The predictive value of RI was evaluated using multivariate logistic regression and receiver operating characteristic ROC curve analyses PCa was identified in 217 4079 patients RI was 069 ± 008 and 08 ± 008 for patients without and with PCa p 001 On logistic regression RI was significantly associated with PCa p 001 Using ROC analysis RI outperformed tPSA in prediction of PCa in all patients area under ROC curve AUC = 083 078 respectively With the cutoff value of 073 RI discriminated PCa from nonPCa patients with 819 sensitivity 759 specificity and 7763 diagnostic accuracy Furthermore The AUC for RI in the discrimination of PCa from nonPCa patients in a subset with PSA of 4 to 10 ng/ml high grade from nonhigh grade PCa patients and advanced from localized PCa patients was 070 077 and 080 higher than other parameters p 005 RI is proved a practicable parameter in identifying patients at risk for PCa and predicting the grade and stage of PCa before initial prostate biopsy The value of RI should be further explored in the futureWe thank all of the subjects included in this study This work was supported by the Jiangsu Province’s Key Medical Talents Program RC2011108 National Natural Science Foundation of China 81272839 Youth project of the National Natural Science Foundation of China 81300537 the outstanding medical academic leader program of Jiangsu Province LJ201138 and the Jiangsu Key Discipline of Medicine XK201151
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