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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1016/0148-9062(92)92360-o

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1559-131X

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Predictive value of pretreatment positron emission

Authors: Bing Bai HuiQiang Huang QiChun Cai Wei Fan XiaoXiao Wang Xu Zhang ZeXiao Lin Yan Gao YunFei Xia Ying Guo QingQing Cai WenQi Jiang TongYu Lin
Publish Date: 2013/01/18
Volume: 30, Issue: 1, Pages: 339-
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Abstract

The role of 18Fluorodeoxyglucose positron emission tomography/computed tomography PET/CT in extranodal natural killer/Tcell lymphoma ENKL is not well established This study aimed to investigate the prognostic role of the pretreatment maximum standardized uptake value SUVmax on PET/CT in patients with newly diagnosed ENKL Among 364 consecutive patients with newly diagnosed ENKL 81 patients were included and reviewed The impact of SUVmax on survival and the relationship between SUVmax and other clinicopathological parameters were analyzed The median SUVmax was 146 range 20–454 The optimal cutoff value of SUVmax to predict overall survival OS was 15 Patients with high SUVmax SUVmax 15 were associated with bulky disease P  0001 local invasion P = 0030 high score of Korean Prognostic Index KPI P = 0046 resistance to primary treatment P = 0014 poor OS P  0001 and unfavorable progressionfree survival P  0001 With a median followup of 250 months the median OS was 630 months range 20–990 months Multivariate analyses revealed the following independent prognostic factors for OS age 60 years P = 0001 stage III–IV P = 0023 SUVmax 15 P = 0020 and bulky disease 5 cm P = 0002 By using the SUVmax patients in most subgroups stratified by the KPI or the International Prognostic Index IPI were further discriminated in OS with significant statistical difference Our results suggest the pretreatment SUVmax is predictive of prognosis in patients with newly diagnosed ENKL The SUVmax may provide additional prognostic information for IPI and KPI

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