Authors: Xiaoqian Wang Karolina Elżbieta KaczorUrbanowicz David T W Wong
Publish Date: 2016/12/10
Volume: 34, Issue: 1, Pages: 7-
Abstract
Cancer is the second most common cause of death in the USA Its symptoms are often not specific and absent until the tumors have already metastasized Therefore there is an urgent demand for developing rapid highly accurate and noninvasive tools for cancer screening early detection diagnostics staging and prognostics Saliva as a multiconstituent oral fluid comprises secretions from the major and minor salivary glands extensively supplied by blood Molecules such as DNAs RNAs proteins metabolites and microbiota present in blood could be also found in saliva Recently salivary diagnostics has drawn significant attention for the detection of specific biomarkers since the sample collection and processing are simple costeffective and precise and do not cause patient discomfort Here we review recent salivary candidate biomarkers for systemic cancers by dividing them according to their origin into genomic transcriptomic proteomic metabolomic and microbial typesDavid Wong is cofounder of RNAmeTRIX Inc a molecular diagnostic company He holds equity in RNAmeTRIX and serves as a company Director and Scientific Advisor The University of California also holds equity in RNAmeTRIX Intellectual property that David Wong invented and which was patented by the University of California has been licensed to RNAmeTRIX The other authors declare no conflict of interest
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