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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1007/s10661-007-0010-y

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1559-131X

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Overexpression of fibrinogenlike protein 2 induce

Authors: WenZheng Qin QuanLin Li WeiFeng Chen MeiDong Xu YiQun Zhang YunShi Zhong LiLi Ma JianWei Hu MingYan Cai MengJiang He LiQing Yao PingHong Zhou
Publish Date: 2014/08/17
Volume: 31, Issue: 9, Pages: 181-
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Abstract

The main cause of death in colorectal carcinoma CRC patients is tumor metastasis however the underlying molecular mechanisms are largely unknown In the present study a novel metastasisrelated gene fibrinogenlike protein 2 FGL2 was characterized for its role in CRC metastasis and underlying molecular mechanisms The clinical significance of FGL2 was investigated using tissue microarray analysis of samples from 82 patients with CRC The molecular effects of FGL2 in CRC cells were determined using RNA interference and ectopic expression of FGL2 The overexpression of FGL2 was examined by immunohistochemistry in 82 CRC patients and it was determined to be an independent predictor of overall survival P  005 The depletion of FGL2 expression inhibited tumor progression and epithelialtomesenchymal transition EMT in vitro and in vivo while ectopic overexpression of FGL2 enhanced cell invasion and induced EMT in vitro Our results suggest that FGL2 plays an important oncogenic role in CRC aggressiveness by inducing EMT and FGL2 could be employed as a novel prognostic marker and effective therapeutic target for CRCThis study was supported by the Grants from the Major Project of Shanghai Municipal Science and Technology Committee 11411950502 and 13411950801 Academic Leader Training Project of Shanghai Municipal Commission of Health and Family Planning 13B038 National Natural Science Foundation of China 81302098 81370588 and 81201902 and Natural Science Foundation of Shanghai 13ZR1452300

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