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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1007/bf00757296

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1559-131X

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Tight junction protein claudin6 inhibits growth a

Authors: Xiaowei Zhang Yang Ruan Yanru Li Dongjing Lin Chengshi Quan
Publish Date: 2015/03/31
Volume: 32, Issue: 5, Pages: 148-
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Abstract

Claudin6 a member of claudin family integral membrane proteins has recently been reported to be a tumor suppressor for breast cancer However whether it plays a role in other types of cancer remains unclear In the present study we showed that the expression of claudin6 is downregulated in cervical carcinoma tissues as revealed by immunohistochemistry Through overexpressing claudin6 in HeLa and C33A cervical carcinoma cells we found that claudin6 is localized at plasma membrane and it increases transepithelial electrical resistance of the cells Gain of claudin6 expression suppresses cell proliferation colony formation in vitro and tumor growth in vivo The effects are accompanied and potentially caused by promotion of tumor cell apoptosis Taken together these results suggest that claudin6 may function as a tumor suppressor and loss of claudin6 contributes to enhanced tumorigenic properties of cervical carcinoma cellsThis study was supported by National Natural Science Foundation of China Code 81172499 and Jilin Province Science and Technology Development Projects 20140414036GH The authors thank Xueni Li Department of Biochemistry and Molecular Genetics University of Colorado Denver USA for help with this manuscript

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