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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1007/bf00211552

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1559-131X

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Rap2B promotes cell proliferation migration and i

Authors: Jiehui Di Huan Cao Juangjuan Tang Zheng Lu Keyu Gao Zhesi Zhu Junnian Zheng
Publish Date: 2016/05/06
Volume: 33, Issue: 6, Pages: 58-
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Abstract

Rap2B a member of the Ras family of small GTPbinding proteins reportedly presents a high level of expression in various human tumors and plays a significant role in the development of tumor However the function of Rap2B in prostate cancer PCa remains unclear We elucidated the stimulative role of Rap2B in PCa cell proliferation migration and invasion by means of the CCK8 cell proliferation assay cell cycle analysis and transwell migration assay Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK suggesting that FAKdependent pathway might be responsible for the effect of Rap2B on PCa cells migration and invasion Inversely FAKspecific inhibitor PF573228 can abort Rap2Binduced FAK phosphorylation In vivo experiment confirmed that Rap2B positively regulated PCa growth and metastasis as well as the expression of phosphorylated FAK Collectively these findings shed light on Rap2B as a potential therapeutic target for PCa

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