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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1007/bf00379787

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ISSN

1559-131X

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Temsirolimus in renal cell carcinoma with sarcomat

Authors: Maria Carmen Areses Urbano Anido Herranz Beatriz Bernárdez Ferrán Luis León Mateos Jorge Garcia González Rafael López López
Publish Date: 2011/05/11
Volume: 29, Issue: 2, Pages: 795-798
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Abstract

Renal cell carcinoma RCC with sarcomatoid features has an aggressive course There is no standard treatment for this histological subtype Some authors have previously reported the use of chemotherapy but the activity of new agents against renal carcinoma with sarcomatoid differentiation has to be formally evaluated Temsirolimus an inhibitor of the mammalian target or rapamycin is active in RCC including those tumors with nonclear histologies We have tested the activity of this agent in three consecutive patients A first patient showed a rapid progression dying 2 months after the diagnosis The second patient showed clinical improvement and a partial response to lung metastasis that was maintained for 14 months The third patient is still alive evaluated as stable disease after 7 months on temsirolimus Importantly toxicity was not a main issue during the use of temsirolimus and only grade 2 hyperglycemia asthenia hyperlipidemia and pleural effusion were detected Temsirolimus is a valid therapy in this subset of patients with some lasting stabilizations and with manageable toxicity

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