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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1002/chin.199543320

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ISSN

1559-131X

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High expression of Transient potential receptor C6

Authors: ShuiShen Zhang Jing Wen Fu Yang XiaoLi Cai Hong Yang KongJia Luo Qian Wen Liu RongGui Hu Xuan Xie QingYuan Huang Jun Ying Chen Jian Hua Fu Yi Hu
Publish Date: 2013/05/18
Volume: 30, Issue: 3, Pages: 607-
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Abstract

TRPC6 plays a crucial role in the tumor progression of various cancers The relation between the expression of TRPC6 and clinical prognosis has not been studied yet Our study was to elucidate the role of TRPC6 in predicting outcomes of patients with esophageal squamous cell carcinoma ESCC Fresh frozen samples were collected immediately from 172 patients with ESCC after surgical resection from 2003 to 2008 at Sun Yatsen University Cancer Center including 45 pairs of tumor tissues and nontumor tissues TRPC6 expression was measured by quantitative realtime PCR and Western blotting analyses TRPC6 mRNA and protein were upregulated in ESCC tissues when compared with the paired nontumor tissues High expression of TRPC6 mRNA was associated with the higher pT status P = 0016 and pathological staging P = 0040 The 5year diseasespecific survival in the high expression of TRPC6 mRNA group 18898 n = 81 is poorer than that in lowlevel expression group ≤18898 n = 91 421 vs 627  P = 0004 Stratified analysis according to the pathological stage revealed its discernibility on DSS was only pronounced in patients with pStage III P = 0015 Cox multivariate analysis revealed that pN category P  0001 Relative risk 2897 95  CI 1830–4585 and the expression of TRPC6 mRNA P = 0006 Relative risk 1863 95  CI 1196–2902 were independent prognostic factors TRPC6 mRNA overexpression correlated with poor prognosis in patients with ESCC and might serve as a novel prognostic biomarker for resected ESCC patients in advanced stage

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