Authors: Y B Shao X F Sun Y N He C J Liu H Liu
Publish Date: 2015/01/09
Volume: 32, Issue: 2, Pages: 5-
Abstract
Primary breast lymphoma PBL is a rare disease accounting for 04–05 of all breast malignancies Accumulating evidence indicates that the diagnosis prognostic factors and optimal management of PBL are difficult The present study aims to investigate the clinicopathological features and optimal treatment of PBL and to evaluate the institutional experience in this patient population A total of 30 patients with PBL from January 2002 to December 2012 treated in He’nan Province Tumor Hospital were selected The patients’ clinical and pathological characteristics treatment and response data patterns of recurrence and outcomes were retrospectively analyzed and the relevant literatures were reviewed All the cases were female and the median age was 45 Diffuse large B cell lymphoma was the most common histological subtype seen in 23 of 30 patients With a median followup time 32 months median OS was 42 months 95 CI 25–58 months with 5year OS rates 48 95 CI 36–59 The median PFS was 14 months 95 CI 6–30 months with 5year PFS rates 32 95 CI 20–45 The prognostic factors that retained statistical significance for OS were IPI P 0001 age P = 004 and stage P 0001 For PFS significant prognostic factors were IPI P = 001 radiotherapy given P = 002 and stage P = 002 PBL appears to have a worse prognosis The present treatment method for PBL is a comprehensive way of diagnostic surgery together with radiotherapy and chemotherapy
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