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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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1559-131X

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PRRX1 promotes epithelial–mesenchymal transition t

Authors: Jinbao Guo Zhongxue Fu Jinlai Wei Weidong Lu Jihong Feng Shouru Zhang
Publish Date: 2014/11/27
Volume: 32, Issue: 1, Pages: 393-
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Abstract

Carcinoma cells hijack the epithelial–mesenchymal transition EMT for tumor dissemination Pairedrelated homeobox 1 PRRX1 has been identified as a new EMT inducer However the function of PRRX1 in gastric cancer has not been elucidated In this study we observed that PRRX1 expression levels were upregulated and positively correlated with metastasis and EMT markers in human gastric cancer specimens PRRX1 overexpression had distinct effects on the cell morphology proliferation migration and invasion of BGC823 and SGC7901 gastric cancer cells both in vitro and in xenografts PRRX1 overexpression resulted in the regulation of the EMT molecular markers Ncadherin Ecadherin and vimentin as well as the levels of intranuclear βcatenin and the Wnt/βcatenin target cMyc Furthermore the inhibition of the Wnt/βcatenin pathway by XAV939 offset the effects of PRRX1 overexpression These findings demonstrate that PRRX1 promotes EMT in gastric cancer cells through the activation of Wnt/βcatenin signaling and that PRRX1 upregulation is closely correlated with gastric cancer metastasis

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