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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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1559-131X

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Protein kinase C PKC as a drug target in chronic

Authors: Julhash U Kazi Nuzhat N Kabir Lars Rönnstrand
Publish Date: 2013/10/31
Volume: 30, Issue: 4, Pages: 757-
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Abstract

Protein kinase C PKC belongs to a family of ten serine/threonine protein kinases encoded by nine genes This family of proteins plays critical roles in signal transduction which results in cell proliferation survival differentiation and apoptosis Due to differential subcellular localization and tissue distribution each member displays distinct signaling characteristics In this review we have summarized the roles of PKC family members in chronic lymphocytic leukemia CLL CLL is a heterogeneous hematological disorder with survival ranging from months to decades PKC isoforms are differentially expressed in CLL and play critical roles in CLL pathogenesis Thus isoformspecific PKC inhibitors may be an attractive option for CLL treatmentWe thank Professor Christer Larsson at Lund University for comments on manuscript This research was funded by the Swedish Cancer Society the Swedish Children’s Cancer Organization the Swedish Research Council Stiftelsen Olle Engkvist Byggmästare Ollie Elof Ericssons Stiftelse Stiftelsen Lars Hiertas Minne Royal Physiographical Society and ALF governmental clinical grant

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