Authors: Hideaki Miyake Kenichi Harada Seiichiro Ozono Masato Fujisawa
Publish Date: 2016/07/21
Volume: 33, Issue: 8, Pages: 95-
Abstract
The objective of this study was to analyze the impact of age on clinical outcomes of metastatic renal cell carcinoma mRCC patients receiving axitinib This study included 144 consecutive mRCC patients who received axitinib for at least 12 weeks as secondline therapy in a routine clinical setting The efficacy safety and quality of life QOL were compared between patients aged 75 n = 116 and ≥75 n = 28 years No significant differences in the clinicopathological characteristics were noted between younger and older patients There was no significant difference in the response rate clinical benefit rate or proportion of patients going on to receive thirdline therapy between these two groups In addition the progressionfree and overall survivals in older patients were similar to those in younger patients There were no significant differences in the incidences of adverse events between these two groups except for that of fatigue which was significantly more frequent in older than younger patients There was no significant difference in the incidence of the discontinuation of axitinib due to adverse events between the two groups QOL assessment at 12 weeks after the introduction of axitinib using the Medical Outcomes Study 36Item Short Form showed no significant differences in any of the eight scale scores between the two groups Taken together it might be possible to achieve clinical outcomes in older patients receiving axitinib comparable to those in younger patients suggesting that advanced age should not be a contraindication to treatment with axitinib as a secondline setting in mRCC patients
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