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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1016/0042-207x(86)90014-x

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1559-131X

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CCR7 pathway induces epithelial–mesenchymal transi

Authors: Jianping Zhang Yunzhe Zhou Yonggang Yang
Publish Date: 2015/01/09
Volume: 32, Issue: 2, Pages: 17-
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Abstract

The chemokine receptor 7 CCR7 and Snail signaling have been linked to various types of cancers The associations between these signalings and the epithelial–mesenchymal transition EMT are not clear in gastric cancer Here the expression of CCR7 and Snail was detected in gastric cancer by immunohistochemistry and Western blot Meanwhile gastric cancer cells were subjected to CCL19 sicontrol and siSnail treatment Cell cycle migration and invasion were also analyzed The expression patterns of CCR7 and Snail were similar in either gastric cancer tissues or cells The increased expression of CCR7 was closely associated with the increased Snail expression which both were closely correlated with metastasis stage and differentiation and poor prognosis The increased pERK pAKT Snail and MMP9 expression and the decreased Ecadherin were confirmed in MGC803 cells in a dosedependent manner in response to CCL19 treatment However the blockade of Snail abrogated the upregulation of MMP9 and downregulation of Ecadherin CCR7induced ERK and PI3K pathway regulated Snail signaling Besides siSnail treatment led to MGC803 cell cycle arrest and affected the migration and invasion In conclusion our study suggested that CCR7 promotes Snail expression to induce the EMT resulting in cell cycle progression migration and invasion in gastric cancer CCR7–Snail pathway provided more potential regimens for cancer therapy

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