Authors: Mirjana Mitrovic Nada Suvajdzic Andrija Bogdanovic Nada Kraguljac Kurtovic Aleksandra Sretenovic Ivo Elezovic Dragica Tomin
Publish Date: 2013/01/31
Volume: 30, Issue: 1, Pages: 478-
Abstract
Highhemorrhagic early death ED rate is a major impediment in the managing of acute promyelocytic leukemia APL In our group of 56 newly diagnosed APL patients ED occurred in 12 subjects due to endocranial bleeding 8/12 differentiation syndrome 2/12 or infection 2/12 Predictors of hemorrhagic ED were as follows white blood cells count ≥20 × 109/L P = 0002337 Eastern cooperative oncology group performance status ≥3 P = 000173 fibrinogen level 2 g/L P = 0004907 prothrombin time 50 P = 00124 and International Society of Thrombosis and Hemostasis Scoring System for disseminated intravascular coagulation ISTH DIC score ≥6 P = 000741 Multivariate analysis indicated ISTH DIC score ≥6 to be the most significant predictor for hemorrhagic ED P = 0008 The main finding of this study is that simple coagulationrelated tests performed on hospital admission and combined in the ISTH DIC score might help to identify patients at high risk for fatal bleeding needing more aggressive supportive measuresThis study was supported by the Ministry of Education and Science Republic of Serbia No 41004 We thank Aleksandra Novkovic for data management and statistical analysis Ana Ivkovic Senior Librarian Institute for Oncology and Radiology of Serbia deserves a special mention for arranging for the relevant articles
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