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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1016/0041-5553(75)90101-9

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1559-131X

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A comparison of measured and estimated glomerular

Authors: A Quinton P Lewis P Ali C Morgan G Bertelli
Publish Date: 2013/07/18
Volume: 30, Issue: 3, Pages: 661-
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Abstract

Dose calculation of adjuvant carboplatin chemotherapy for stage I testicular seminoma based on area under the concentration curve AUC incorporates the glomerular filtration rate GFR This retrospective study compares ‘gold standard’ 51Crethylenediamine tetraacetic acid 51CrEDTA GFR measurements with renal function estimations derived from the Cockcroft–Gault Jelliffe and Wright formulae Inclusion criteria stage I testicular seminoma treated with a single dose of carboplatin AUC7 at one centre in South Wales UK between 2005 and 2011 with contemporaneous 51CrEDTA GFR measurement and serum creatinine Renal function estimates obtained using Cockcroft–Gault Jelliffe and Wright formulae were analysed for bias mean percentage error MPE and precision mean absolute percentage error MAPE compared to the gold standard Sixtyeight patients were identified median age 40 range 17–66 median creatinine 82 range 55–120 For the Cockcroft–Gault Jelliffe and Wright formulae respectively MPE was +124 −323 and +88 MAPE was 160 327 and 129 and substitution of the calculated GFR result for 51CrEDTA measurement would have resulted in a 10  discrepancy in carboplatin dose in 411 971 and 426  of patients predominantly overdoses for the Cockcroft–Gault and Wright formulae underdoses for the Jelliffe formula Of the formulae analysed none accurately correlated with 51CrEDTA GFR measurements

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