Authors: Ming Wang Jia Xu Wenyi Zhao Lin Tu Weiqing Qiu Chaojie Wang Yangyin Shen Qiang Liu Hui Cao
Publish Date: 2013/12/14
Volume: 31, Issue: 1, Pages: 819-
Abstract
The objective of this study was to investigate the impact of KIT/PDGFRA mutations on the prognosis of gastrointestinal stromal tumors GISTs In the present study genotype analyses were performed based on GIST samples from 275 patients The relationship between mutation and clinicopathological characteristics were explored All factors were evaluated for their impacts on relapsefree survival RFS Briefly the results of genotype analyses showed that mutations were identified in 258 938 patients and deletion was the most frequent type of mutation accounting for 473 122/258 of all mutation cases followed by substitution 87/258 337 and duplication 49/258 190 Moreover for KIT exon 11 mutation the most frequently involved area was from codon 557 to 560 Deep analyses showed that the mutation types were correlated with tumor location P = 0005 tumor size P = 0022 mitosis rate P 0001 risk grade P 0001 and relapse P = 0004 Furthermore delW557K558 correlated with mitosis rate P = 0042 and relapse P = 0036 and delTyr568/570 correlated with tumor origin P = 0018 Most importantly mitotic rate HR = 2901 95 CI 1094–7695 P = 0032 and risk grade HR = 9629 95 CI 1997–46416 P = 0005 would be the representative traditional prognostic factors and deletion with 3 codons would be an novel independent predictor of poor outcome for RFS in GIST patients with deletion mutation of KIT exon 11 HR = 7970 95 CI 1774–35803 P = 0007 All results indicated that mutation determined clinicopathological features and prognosis of GISTs and more than three codons involvement may be a novel adverse indicator
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