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Title of Journal: Med Oncol

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Abbravation: Medical Oncology

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Springer US

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DOI

10.1007/978-3-322-86354-6

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1559-131X

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Downregulation of microRNA100 correlates with tum

Authors: Peng Chen Qiulei Xi Qiang Wang Pei Wei
Publish Date: 2014/09/13
Volume: 31, Issue: 10, Pages: 235-
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Abstract

Dysregulation of microRNA100 miR100 has been shown to be involved in cancer tumorigenesis and progression of several cancer types However its expression patterns in tumors are controversial The aim of this study was to investigate the expression and clinical significance of miR100 in colorectal cancer CRC Quantitative realtime PCR was used to analyze the expression of miR100 in 138 pairs of human CRC and adjacent normal tissues The prognostic values of miR100 in CRC were also analyzed The results showed that the miR100 expression was significantly downregulated in CRC tissues when compared to adjacent normal tissues P  0001 Also low miR100 expression was observed to be significantly correlated with larger tumor size P = 0023 higher incidence of lymph node metastasis P = 0009 and advanced TNM stage P = 0016 More importantly Kaplan–Meier analysis showed that CRC patients with low miR100 expression tended to have shorter overall survival In multivariate analysis stratified for known prognostic variables low miR100 expression was identified as an independent prognostic factor for overall survival In conclusion our data indicated for the first time that the downregulation of miR100 was associated with advanced clinical features and poor prognosis of CRC patients suggesting that miR100 downregulation may serve as an unfavorable prognostic biomarker in CRC

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