Authors: Van Hoof L M J J
Publish Date: 1947/07/01
Volume: 40, Issue: 6, Pages: 727-761
Abstract
L M J J Van Hoof The Second Royal Society of Tropical Medicine and Hygiene Chadwick Lecture Observations on trypanosomissis in the Belgian Congo Transactions of The Royal Society of Tropical Medicine and Hygiene Volume 40 Issue 6 July 1947 Pages 727–761 https//doiorg/101016/0035920347900345The resistance of T gambiense to pentavalent arsenicals especially to tryparsamide is not due only to the action of subcurative doses it can exist as a natural characteristic of certain strains This resistance is often difficult to create in the laboratory and the routine treatment given to patients does not inevitably increase it in the case of a relapseIn old endemic areas there exist alongside nonresistant strains which are generally easily transmitted varieties of resistant ones which are sufficiently easily transmitted and which maintain the percentage of resistant cases and finally resistant strains which are hardly transmissible at all are found in chronic treated patients and relapsing cases
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