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Title of Journal: Trans R Soc Trop Med Hyg

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Abbravation: Transactions of The Royal Society of Tropical Medicine and Hygiene

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Narnia

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10.1007/s10603-013-9245-x

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0035-9203

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Plasmodium falciparum sensitivity to chloroquine

Authors: Afari EA Akanmori BD Nakano T OforiAdjei D
Publish Date: 1992/06/01
Volume: 86, Issue: 3, Pages: 231-232
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Abstract

EA Afari BD Akanmori T Nakano D OforiAdjei Plasmodium falciparum sensitivity to chloroquine in vivo in three ecological zones in Ghana Transactions of The Royal Society of Tropical Medicine and Hygiene Volume 86 Issue 3 MayJune 1992 Pages 231–232 https//doiorg/101016/003592039290285K4690 children aged 6–15 years in 5 urban and 4 rural communities in 3 ecological zones in Ghana were screened from June 1988 to December 1990 to provide suitable candidates for the World Health Organization standard in vivo test for susceptibility of Plasmodium falciparum to chloroquine 1880 40·1 had parasitaemia mostly 83·7–98·6 due to P falciparum infection Of the 626 in vivo tests performed 570 91·1 showed sensitivity to chloroquine and 56 8·9 responses were classified as resistant to chloroquine at RI 5·1 and RII 3·8 The resistance responses were commonest 17·1–22·7 in the coastal zone followed by the savanna zone 8·6–10·0 and lowest in the forest zone 3·1–6·3 The RII responses occurred mainly in communities in the coastal zone There was no RIII resistance in any zone The pattern of RI early and RII responses of P falciparum to chloroquine in this study suggested an increase in sensitivity or a reduction in resistance of P falciparum to chloroquine from the coast to the forest and northern savanna zones and from the urban to the rural communities in each zone in Ghana

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References

citation title=The changing pattern of Plasmodium falciparum susceptibility to chloroquine but not to mefloquine in a mesoendemic area of Somalia Transactions of the Royal Society of Tropical Medicine and Hygiene citation year=1991 citation volume=85 citation pages=200203

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