Authors: Nosten François
Publish Date: 1994/06/01
Volume: 88, Issue: Supplement_1, Pages: 45-46
Abstract
Prospective randomized trials with oral artemisinin derivatives have been conducted in over 1000 patients to determine the optimum treatment of multidrug resistant falciparum malaria on the ThaiBurmese border These drugs have proved valuable in 3 settings i Primary treatment of uncomplicated malaria in combination with mefloquine when they accelerate the rate of recovery eliminate the risk of dangerous early failures and if given for 3 d or more improve overall cure rates ii treatment of recrudescent infections which otherwise have a high failure rate and iii oral treatment of patients with high parasitaemias ⩾4 but no clinical evidence of severity a group who would usually receive parenteral quinine The parenteral formulation of artemether is absorbed if given rectally and this may offer a practical alternative method of treating severe malaria in rural areas
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