Authors: Gbakima Aiah A ElSadr Wafaa Greene Bruce M
Publish Date: 1986/01/01
Volume: 80, Issue: 2, Pages: 305-308
Abstract
Aiah A Gbakima Wafaa ElSadr Bruce M Greene Delayed isotype switching in Dirofilaria immitis infection Transactions of The Royal Society of Tropical Medicine and Hygiene Volume 80 Issue 2 1986 Pages 305–308 https//doiorg/101016/0035920386900428The antimicrofilarial immunoglobulin response in Dirofilaria immitis infection was investigated serially in a naturally infected dog Spontaneous clearance of microfilariae was associated with IgM opsonizing antibodies which promoted in vitro killing of microfilariae by granulocytes Over a 6to 11month period there was a shift to a predominantly IgG response The addition of fresh nonimmune serum markedly enhanced killing mediated by both IgM and IgG The findings document conversion from IgM to IgG isotype with chronic infection and suggest that isotype switching in canine D immitis infection is delayed relative to that seen in bacterial or viral infections
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