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Title of Journal: Trans R Soc Trop Med Hyg

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Abbravation: Transactions of The Royal Society of Tropical Medicine and Hygiene

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Narnia

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DOI

10.1007/bf02514789

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0035-9203

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The influence of treatment on the development and

Authors: Warren Kenneth S
Publish Date: 1962/11/01
Volume: 56, Issue: 6, Pages: 510-519
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Abstract

Kenneth S Warren The influence of treatment on the development and course of murine hepatosplenic schistosomiasis mansoni Transactions of The Royal Society of Tropical Medicine and Hygiene Volume 56 Issue 6 November 1962 Pages 510–519 https//doiorg/101016/0035920362900755Previous studies have shown that mice treated at 5 weeks following infection with Schistosoma mansoni developed no disease whereas their untreated counterparts rapidly developed hepatosplenic schistosomiasis These findings were confirmed in the present study and in addition it was found that mice treated at 75 weeks when there were many eggs in the liver and at 10 weeks when hepatosplenic schistosomiasis was fully developed rapidly reverted to normal in regard to portal pressure and liver and spleen sizeHaving eliminated the source of eggs by killing the worms it was possible to study the devolution of the egg lesions that were already present The inflammatory cells rapidly disappeared followed thereafter by a relatively sudden resorption of fibrous tissue Between 25 and 52 weeks following treatment there was an almost complete disappearance of all egg lesions

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References

J Parasit citation year=1947 citation volume=33 citation pages=419

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